Basic information of FTO :
| Official Symbol of Gene | FTO |
| Species | Homo sapiens |
| Entrez Gene ID | 79068 |
| Official Full Name | FTO alpha-ketoglutarate dependent dioxygenase |
| Also known as | GDFD; ALKBH9; BMIQ14 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000140718 MIM:610966; AllianceGenome:HGNC:24678 |
| Map Location | 16q12.2 |
| Variation Type | SNP |
| refSNP ID | rs9939609 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | Real-time PCR |
| Disease | MS |
| Disease subtype | RRMS, SPMS |
| Population | Kuwaiti |
| Sample Size | 200 MS / 206 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 31836807 |
| Year | 2019 |
| Title | The FTO gene polymorphism rs9939609 is associated with obesity and disability in multiple sclerosis patients |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | FTO rs9939609 genotype distribution in the MS cohort did not differ from the sampled healthy Kuwaiti population distributions after adjusting for both age and gender under both an additive and recessive genetic model. |
| Mechanism/Pathway | The FTO is an alpha-ketoglutarate dependent dioxygenase that is highly expressed in the nucleus.It is reported to be an RNA demethylase that mediates demethylation of different RNA species including mRNAs, tRNAs and snRNAs. |
