Basic information of FTO :
| Official Symbol of Gene | FTO |
| Species | Homo sapiens |
| Entrez Gene ID | 79068 |
| Official Full Name | FTO alpha-ketoglutarate dependent dioxygenase |
| Also known as | GDFD; ALKBH9; BMIQ14 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000140718 MIM:610966; AllianceGenome:HGNC:24678 |
| Map Location | 16q12.2 |
| Variation Type | SNP |
| refSNP ID | rs9939609 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | Real-time PCR |
| Disease | MS |
| Disease subtype | RRMS, SPMS |
| Population | Kuwaiti |
| Sample Size | 200 MS / 206 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 31836807 |
| Year | 2019 |
| Title | The FTO gene polymorphism rs9939609 is associated with obesity and disability in multiple sclerosis patients |
Results of multiple sclerosis :
| Risk Type | Phenotypic risk |
| Main Result | Positive |
| Result | The A-allele was found to be associated with increased MS disability. |
| Mechanism/Pathway | The FTO is an alpha-ketoglutarate dependent dioxygenase that is highly expressed in the nucleus.It is reported to be an RNA demethylase that mediates demethylation of different RNA species including mRNAs, tRNAs and snRNAs. |
