Basic information of GSTP1 :
| Official Symbol of Gene | GSTP1 |
| Species | Homo sapiens |
| Entrez Gene ID | 2950 |
| Official Full Name | glutathione S-transferase pi 1 |
| Also known as | PI; DFN7; GST3; GSTP; FAEES3; HEL-S-22 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000084207 MIM:134660; AllianceGenome:HGNC:4638 |
| Map Location | 11q13.2 |
| Variation Type | polymorphism |
| refSNP ID | A313 G |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR-RFLP |
| Disease | MS |
| Disease subtype | RRMS, PPMS, SPMS, RPMS |
| Population | Greek |
| Sample Size | 254 MS patients / 370 healthy individuals |
Literature information of multiple sclerosis :
| Pubmed ID | 24588223 |
| Year | 2015 |
| Title | Combined GSTP1 and NQO1 germline polymorphisms in the susceptibility to Multiple Sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | Comparison of the genotype distribution between MS cases and controls revealed no significant differences.Allele frequencies distribution analysis showed similar A and G allele frequencies for both MS patients and controls. |
| Mechanism/Pathway | Germline polymorphisms of detoxification genes could influence susceptibility to Multiple Sclerosis (MS).Glutathione-S-transferases (GSTs) is detoxifying enzymes involved in biotransformation of metabolites preventing cells from oxidative damage. |
