Basic information of NQO1 :
| Official Symbol of Gene | NQO1 |
| Species | Homo sapiens |
| Entrez Gene ID | 1728 |
| Official Full Name | NAD(P)H quinone dehydrogenase 1 |
| Also known as | DTD; QR1; DHQU; DIA4; NMOR1; NMORI |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000181019 MIM:125860; AllianceGenome:HGNC:2874 |
| Map Location | 16q22.1 |
| Variation Type | polymorphism |
| refSNP ID | C609 T |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | Real-Time PCR |
| Disease | MS |
| Disease subtype | RRMS, PPMS, SPMS, RPMS |
| Population | Greek |
| Sample Size | 254 MS patients / 370 healthy individuals |
Literature information of multiple sclerosis :
| Pubmed ID | 24588223 |
| Year | 2015 |
| Title | Combined GSTP1 and NQO1 germline polymorphisms in the susceptibility to Multiple Sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The frequencies of variant NQO1 genotypes were significantly higher in MS cases as compared to the controls.Similarly, the T allele frequency was increased in MS patients. |
| Mechanism/Pathway | Germline polymorphisms of detoxification genes could influence susceptibility to Multiple Sclerosis (MS).NAD(P)H:quinone oxidoreductase 1 (NQO1) is detoxifying enzymes involved in biotransformation of metabolites preventing cells from oxidative damage. |
