Basic information of MT-ND4 :
| Official Symbol of Gene | MT-ND4 |
| Species | Homo sapiens |
| Entrez Gene ID | 4538 |
| Official Full Name | mitochondrially encoded NADH dehydrogenase 4 |
| Also known as | MTND4; ND4 |
| Gene Type | protein coding |
| dbXrefs | MIM:516003; AllianceGenome:HGNC:7459 |
| Map Location | N/A |
| Variation Type | polymorphism |
| refSNP ID | Nt 11353 T>C, Nt 11935 T>C, Nt 12062 C>T |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Filipino |
| Sample Size | 200 MS / 100 healthy subjects |
Literature information of multiple sclerosis :
| Pubmed ID | 25172194 |
| Year | 2014 |
| Title | Mitochondrial complex I gene variations; as a potential genetic risk factor in pathogenesis of multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Our results indicated that the prevalence of ND4 gene variations was significantly higher in patients than in healthy controls.We failed to detect Nt 11353 T>C, Nt 11935 T>C variations in the control group.The Nt 12062 C>T variation in the females of the case group was significantly higher than that in males whereas, there is no significant difference in the prevalence of remnant variations between males and females of the case group.The Nt 12062 C>T variations in the females of the patient group were significantly higher than those in the females of the control group . |
| Mechanism/Pathway | The mitochondria can play fundamental roles in the pathogenesis of MS.Complex I deficiency may contribute to disease susceptibility in MS. |
