Basic information of MT-ND5 :
| Official Symbol of Gene | MT-ND5 |
| Species | Homo sapiens |
| Entrez Gene ID | 4539 |
| Official Full Name | mitochondrially encoded NADH dehydrogenase 5 |
| Also known as | MTND5; ND5 |
| Gene Type | protein coding |
| dbXrefs | MIM:516005; AllianceGenome:HGNC:7461 |
| Map Location | N/A |
| Variation Type | polymorphism |
| refSNP ID | Nt 13042 G>A, Nt 13708 G>A |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Filipino |
| Sample Size | 200 MS / 100 healthy subjects |
Literature information of multiple sclerosis :
| Pubmed ID | 25172194 |
| Year | 2014 |
| Title | Mitochondrial complex I gene variations; as a potential genetic risk factor in pathogenesis of multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Our results indicated that the prevalence of ND5 gene variations was significantly higher in patients than in healthy controls.We failed to detect Nt 13708 G>A variations in the control group. The Nt 13042 G>A variations in males of the patient group were significantly higher than those in the males of the control group.The Nt 13042 G>A variations in the females of the patient group were significantly higher than those in the females of the control group . |
| Mechanism/Pathway | The mitochondria can play fundamental roles in the pathogenesis of MS.Complex I deficiency may contribute to disease susceptibility in MS. |
