Basic information of TRA :

Official Symbol of Gene	TRA
Species	Homo sapiens
Entrez Gene ID	6955
Official Full Name	T cell receptor alpha locus
Also known as	IMD7; TCRA; TRA@
Gene Type	protein coding
dbXrefs	AllianceGenome:HGNC:12027
Map Location	14q11.2
Variation Type	polymorphism
refSNP ID	N/A

Sample information of multiple sclerosis:

Detected Sample	venous blood
Sample Detail	N/A
Detected Method	RFLP and a microsatellite repeat polymorphism
Disease	MS
Disease subtype	N/A
Population	British Isles
Sample Size	131 sibling pairs

Literature information of multiple sclerosis :

Pubmed ID	7931419
Year	1994
Title	No linkage between multiple sclerosis and the T cell receptor alpha chain locus

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Negative
Result	The observed frequencies of haplotype sharing did not differ from expected rates and these results provide no evidence for linkage between the TCRa locus and susceptibility to MS.
Mechanism/Pathway	Immune mechanisms are involved in the pathogenesis of MS. The areas of demyelination are infiltrated by lymphocytes and activated macrophages and various cytokines.Associations between MS and major histocompatibility complex (MHC) antigens are well established.Interactions occur between the MHC molecule, antigen and the heterodimeric T cell receptor (TCR) and this recognition process has stimulated interest in the role of TCR germline genes as additional candidates for susceptibility in a number of autoimmune diseases.