Basic information of NR3C1 :

Official Symbol of Gene	NR3C1
Species	Homo sapiens
Entrez Gene ID	2908
Official Full Name	nuclear receptor subfamily 3 group C member 1
Also known as	GR; GCR; GRL; GCCR; GCRST
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000113580 MIM:138040; AllianceGenome:HGNC:7978
Map Location	5q31.3
Variation Type	polymorphism
refSNP ID	N363S, ER22/23EK, BclIG

Sample information of multiple sclerosis:

Detected Sample	PBMC
Sample Detail	N/A
Detected Method	Allelic Discrimination Assays
Disease	MS
Disease subtype	RRMS, PPMS, SPMS
Population	Dutch
Sample Size	103 MS patients / 33 healthy controls

Literature information of multiple sclerosis :

Pubmed ID	16083972
Year	2005
Title	The impact of glucocorticoid receptor gene polymorphisms on glucocorticoid sensitivity is outweighted in patients with multiple sclerosis

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Positive
Result	For the ER22/23EK and the N363S variants no homozygous carriers were found.Genotype frequencies were not significantly different between HC and MS patients and the MS subgroups.The two other polymorphisms were not related to GC sensitivity.We defined 'real non-carriers' as having neither the N363S nor the BclIG allele.'Carriers' were cases carrying both the N363S and the BclIG allele.When only one of these polymorphisms was present, cases were defined as 'partly carriers'.In HC, 'real non-carriers' (carrying neither the N363S nor the BclIG allele) were significantly more sensitive to GC compared to 'partly carriers' .In MS patients there was no significant difference.
Mechanism/Pathway	In several inflammatory or autoimmune diseases,evidence of decreased GC sensitivity of blood cells has been reported.Within the normal population, several polymorphisms have been described.At least three of these have been associated with altered GC sensitivity in vivo in healthy controls ,which is involved in the transactivation process.