Basic information of TRB :
| Official Symbol of Gene | TRB |
| Species | Homo sapiens |
| Entrez Gene ID | 6957 |
| Official Full Name | T cell receptor beta locus |
| Also known as | TCRB; TRB@ |
| Gene Type | protein coding |
| dbXrefs | AllianceGenome:HGNC:12155 |
| Map Location | 7q34 |
| Variation Type | expansion |
| refSNP ID | Vβ17 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | peripheral blood T cells |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | PPMS, RRMS |
| Population | N/A |
| Sample Size | MS patients (n=42) and healthy individuals (n=30) |
Literature information of multiple sclerosis :
| Pubmed ID | 12707368 |
| Year | 2003 |
| Title | Complementarity-determining region 3 spectratyping analysis of the TCR repertoire in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | The frequency of Vβ expansion in healthy subjects and patients with MS during active and remission phasesa |
| Mechanism/Pathway | immunotherapy with TCR DNA vaccines targeting Vβs selected by spectratyping analysis successfully suppressed the development of autoimmune diseases. |
