Basic information of WT1 :
| Official Symbol of Gene | WT1 |
| Species | Mus musculus |
| Entrez Gene ID | 7490 |
| Official Full Name | WT1 transcription factor |
| Also known as | GUD; AWT1; WAGR; WT-1; WT33; NPHS4; WIT-2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000184937 MIM:607102; AllianceGenome:HGNC:12796 |
| Map Location | 11p13 |
| Variation Type | SNP |
| refSNP ID | rs10767935, rs5030244 |
Sample information of multiple sclerosis:
| Detected Sample | serum |
| Sample Detail | N/A |
| Detected Method | predesigned Taqman SNP genotyping assays |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Norwegian |
| Sample Size | 85 RRMS patients |
Literature information of multiple sclerosis :
| Pubmed ID | 26037530 |
| Year | 2016 |
| Title | WT1 and interferon-β-vitamin D association in MS: a longitudinal study |
Results of multiple sclerosis :
| Risk Type | Treatment risk |
| Main Result | Negative |
| Result | In this prospective study with repeated measurements of 25-hydroxyvitamin D before and during treatment with IFN-β, we did not find that genetic variation in WT1 plays any role in regulating the relationship between IFN-β and serum 25-hydroxyvitamin D. |
| Mechanism/Pathway | High serum levels of vitamin D have been shown to be associated with low risk of developing multiple sclerosis (MS) and are also associated with low clinical and radiological disease activity . IFN-b treatment was associated with reduced relapse risk only in patients with serum 25(OH)D above 50 nmol/l, suggesting that the effect of IFN-b was mediated through 25(OH)D. |
