Basic information of Vav1 :
| Official Symbol of Gene | Vav1 |
| Species | Mus musculus |
| Entrez Gene ID | 22324 |
| Official Full Name | vav 1 oncogene |
| Also known as | Vav; vav-T |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000034116 AllianceGenome:MGI:98923 |
| Map Location | 17 D; 17 29.76 cM |
| Variation Type | polymorphism |
| refSNP ID | Vav1R63W |
Sample information of multiple sclerosis:
| Detected Sample | N/A |
| Sample Detail | N/A |
| Detected Method | knock-in |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6 mice |
| Sample Size | 13 KI mice / 4 WT |
Literature information of multiple sclerosis :
| Pubmed ID | 27438086 |
| Year | 2016 |
| Title | A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Vav1R63W mice display reduced susceptibility to experimental autoimmune encephalomyelitis (EAE) induced by MOG35-55 peptide immunization.Although the incidence of the disease was similar between the two groups, Vav1R63W mice developed a less severe disease, with delayed onset and quicker recovery resulting in reduced clinical scores .However, the CNS-infiltrating CD4 T cells from both the brain and spinal cord of MOG35-55-immunized Vav1R63W mice produced significantly less IFN-γ, IL-17 and GM-CSF. |
| Mechanism/Pathway | The guanine nucleotide exchange factor (GEF) Vav1 is essential for transducing T cell antigen receptor (TCR) signals and therefore plays a critical role in the development and activation of T cells.A recent study has shown that many critical events involved in T cell activation are mediated by either the GEF or the scaffolding activities of Vav1.The GEF activity of Vav1 is necessary for T cell development and for the optimal activation of T cells, including signal transduction to Rac1, Akt, and integrins. |
