Basic information of HAMP :
| Official Symbol of Gene | HAMP |
| Species | Homo sapiens |
| Entrez Gene ID | 57817 |
| Official Full Name | hepcidin antimicrobial peptide |
| Also known as | HEPC; PLTR; HFE2B; LEAP1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000105697 MIM:606464; AllianceGenome:HGNC:15598 |
| Map Location | 19q13.12 |
| Variation Type | SNP |
| refSNP ID | rs10421768 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood leukocytes |
| Sample Detail | N/A |
| Detected Method | Real-time PCR |
| Disease | MS |
| Disease subtype | RRMS, PPMS, SPMS |
| Population | N/A |
| Sample Size | 176 MS patients |
Literature information of multiple sclerosis :
| Pubmed ID | 35682458 |
| Year | 2022 |
| Title | Hepcidin (rs10421768), Transferrin (rs3811647, rs1049296) and Transferrin Receptor 2 (rs7385804) Gene Polymorphism Might Be Associated with the Origin of Multiple Sclerosis |
Results of multiple sclerosis :
| Risk Type | Phenotypic risk |
| Main Result | Positive |
| Result | A statistical trend has been shown regarding the tendency to occur primary relapses more frequently among persons with the AA + AG genotype compared with GG patients in the recessive HAMP rs10421768 inheritance model. |
| Mechanism/Pathway | The mechanism of iron regulation in the cell by HAMP is mainly based on the control of FPN expression at the level of its translation.The presence of polymorphisms in the genes of iron metabolism may modulate iron deposition in the body and thus affect the clinical course of the disease. |
