Basic information of TF :
| Official Symbol of Gene | TF |
| Species | Homo sapiens |
| Entrez Gene ID | 7018 |
| Official Full Name | transferrin |
| Also known as | TFQTL1; PRO1557; PRO2086; HEL-S-71p |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000091513 MIM:190000; AllianceGenome:HGNC:11740 |
| Map Location | 3q22.1 |
| Variation Type | SNP |
| refSNP ID | rs1049296 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood leukocytes |
| Sample Detail | N/A |
| Detected Method | Real-time PCR |
| Disease | MS |
| Disease subtype | RRMS, PPMS, SPMS |
| Population | N/A |
| Sample Size | 176 MS patients |
Literature information of multiple sclerosis :
| Pubmed ID | 35682458 |
| Year | 2022 |
| Title | Hepcidin (rs10421768), Transferrin (rs3811647, rs1049296) and Transferrin Receptor 2 (rs7385804) Gene Polymorphism Might Be Associated with the Origin of Multiple Sclerosis |
Results of multiple sclerosis :
| Risk Type | Phenotypic risk |
| Main Result | Positive |
| Result | In the case of the rs1049269 codominant model of the TF polymorphism, the analysis showed that people with the CT genotype scored statistically significantly lower points in the EDSS scale at the diagnosis of the disease than those with the CC genotype . |
| Mechanism/Pathway | TF plays a key role in the distribution and maintenance of iron homeostasis.It intermediates between the places of its storage, absorption, and use, delivering to all cells, including BVECs.The presence of polymorphisms in the genes of iron metabolism may modulate iron deposition in the body and thus affect the clinical course of the disease. |
