Basic information of IL7R :

Official Symbol of Gene	IL7R
Species	Homo sapiens
Entrez Gene ID	3575
Official Full Name	interleukin 7 receptor
Also known as	ILRA; CD127; IL7RA; CDW127; IMD104; sIL-7R; lnc-IL7R; IL7Ralpha; IL-7Ralpha; IL-7R-alpha
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000168685 MIM:146661; AllianceGenome:HGNC:6024
Map Location	5p13.2
Variation Type	haplotype
refSNP ID	Hap 1, Hap 2, Hap 4

Sample information of multiple sclerosis:

Detected Sample	PBMC
Sample Detail	EDTA-treated whole blood
Detected Method	semiquantitative RT-PCR
Disease	MS
Disease subtype	N/A
Population	Western Sydney
Sample Size	N/A

Literature information of multiple sclerosis :

Pubmed ID	24147013
Year	2013
Title	IL7Rα expression and upregulation by IFNβ in dendritic cell subsets is haplotype-dependent

Results of multiple sclerosis :

Risk Type	Treatment risk
Main Result	Positive
Result	Similar to our previous findings in CD4 T cells, IL7Rα Hap 4 was not upregulated in response to IFNβ in any of the subsets. In contrast, Hap 1 was upregulated in all subsets in response to IFNβ, and mean Hap 2 IL7Rα levels were increased in all subsets. As a result, Hap 4 was consistently expressed at the lowest level of all the haplotypes in all IFNβ-treated cells, significantly lower than Hap 1 and Hap 2 in maturing DCs. In response to IFNβ, IL7Rα Hap 4 transcript (rs3194051 ‘G’) was expressed at a relatively lower level compared to Hap 1 or Hap 2 (both rs3194051 ‘A’) than in the absence of IFNβ. A significant proportion of the combined cohort decreased relative expression of Hap4 in response to IFNβ when the 3 cell subsets were included in the analysis; this did not reach significance for individual groups or cell subsets, The trend was the same in MS and controls.
Mechanism/Pathway	We found an association of the interleukin-7 receptor α chain (IL7Rα) with MS and have identified key functional differences between IL7Rα haplotypes that are likely to affect MS susceptibility.IL7Rα is a subunit of receptors for IL-7 and thymic stromal lymphopoietin (TSLP) and is expressed on T cells, dendritic cells (DCs) and other myeloid cells.IL-7 is a critical and nonredundant cytokine mediating survival and differentiation of T cells and their progenitors.IL7Rα has four major haplotypes.Haplotype 2 (Hap 2) is protective against MS and cells exhibit reduced splicing of exon 6 from the transcript, producing less of a soluble isoform (sIL7Rα).IL7Rα signaling exerts powerful effects on myeloid cell function, dependent on the microenvironment and on differentiation status.