Basic information of CCR5 :
| Official Symbol of Gene | CCR5 |
| Species | Homo sapiens |
| Entrez Gene ID | 1234 |
| Official Full Name | C-C motif chemokine receptor 5 |
| Also known as | CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000160791 MIM:601373; AllianceGenome:HGNC:1606 |
| Map Location | 3p21.31 |
| Variation Type | polymorphism |
| refSNP ID | promoter -2459 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | modified multiplex PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Caucasian |
| Sample Size | 109 MS patients / 105 healthy volunteers |
Literature information of multiple sclerosis :
| Pubmed ID | 17511851 |
| Year | 2007 |
| Title | Chemokine receptor CCR5 in interferon-treated multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Treatment risk |
| Main Result | Negative |
| Result | The attack risk was not associated with the CCR5 promoter genotype in this sample of IFN-b-treated MS patients. |
| Mechanism/Pathway | Multiple sclerosis (MS) is characterized by T cell and monocyte infiltration in the central nervous system.The CC chemokine receptor CCR5 has been implicated in the pathogenesis of MS as mononuclear cells. |
