Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | allele |
| refSNP ID | DRB1*0301 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | PCR sequence-specific primer method |
| Disease | MS |
| Disease subtype | RRMS, PPMS, SPMS, RPMS |
| Population | Israeli Arab |
| Sample Size | 43 Christians and 66 Muslims MS patients / 42 Christians and 90 Muslims controls |
Literature information of multiple sclerosis :
| Pubmed ID | 20463743 |
| Year | 2010 |
| Title | Opposing effects of the HLA-DRB1*0301-DQB1*0201 haplotype on the risk for multiple sclerosis in diverse Arab populations in Israel |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | HLA class II analyses Case–control analysis was significant for the HLA-DRB1 gene in both the Muslim and the Christian populations.Further analysis indicated that in the Muslim population, DRB1*0301 is a major susceptibility allele, positively associated to MS.Surprisingly, in the Christian Arab population the DRB1*0301 allele was negatively associated with MS. Moreover, DRB1*0301 homozygotes were observed only in the Christian control group. |
| Mechanism/Pathway | Multiple sclerosis (MS) is a neurological disease with a strong inflammatory component.The major genetic effect has been attributed to the 6p major histocompatibility complex region, comprising the human leukocyte antigen (HLA) genes. |
