Basic information of HLA-DQB1 :
| Official Symbol of Gene | HLA-DQB1 |
| Species | Homo sapiens (human) |
| Entrez Gene ID | 3119 |
| Official Full Name | major histocompatibility complex, class II, DQ beta 1 |
| Also known as | IDDM1; CELIAC1; HLA-DQB |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000179344 MIM:604305; AllianceGenome:HGNC:4944 |
| Map Location | 6p21.32 |
| Variation Type | allele |
| refSNP ID | DQB1*0201 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | PCR sequence-specific primer method |
| Disease | MS |
| Disease subtype | RRMS, PPMS, SPMS, RPMS |
| Population | Israeli Arab |
| Sample Size | 109 MS patients / 132 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 20463743 |
| Year | 2010 |
| Title | Opposing effects of the HLA-DRB1*0301-DQB1*0201 haplotype on the risk for multiple sclerosis in diverse Arab populations in Israel |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Analysis of the DQB1 locus revealed a significant difference between cases and controls in the Muslim, and trend for the Christian population.Positive association of the HLA-DQB1*0201 allele in Muslims, and negative association in Christian Arabs. |
| Mechanism/Pathway | Multiple sclerosis (MS) is a neurological disease with a strong inflammatory component.The major genetic effect has been attributed to the 6p major histocompatibility complex region, comprising the human leukocyte antigen (HLA) genes. |
