Basic information of HLA-B :
| Official Symbol of Gene | HLA-B |
| Species | Homo sapiens |
| Entrez Gene ID | 3106 |
| Official Full Name | major histocompatibility complex, class I, B |
| Also known as | AS; HLAB; B-4901 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000234745 MIM:142830; AllianceGenome:HGNC:4932 |
| Map Location | 6p21.33 |
| Variation Type | allele |
| refSNP ID | HLA-B*52 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | PCR sequence-specific primer method |
| Disease | MS |
| Disease subtype | RRMS, PPMS, SPMS, RPMS |
| Population | Israeli Arab |
| Sample Size | 109 MS patients / 132 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 20463743 |
| Year | 2010 |
| Title | Opposing effects of the HLA-DRB1*0301-DQB1*0201 haplotype on the risk for multiple sclerosis in diverse Arab populations in Israel |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The HLA-B*52 allele remained significant after correcting for multiple testing, was negatively associated with MS and totally absent from the patient population. |
| Mechanism/Pathway | Multiple sclerosis (MS) is a neurological disease with a strong inflammatory component.The major genetic effect has been attributed to the 6p major histocompatibility complex region, comprising the human leukocyte antigen (HLA) genes. |
