Basic information of IL2RA :
| Official Symbol of Gene | IL2RA |
| Species | Homo sapiens |
| Entrez Gene ID | 3559 |
| Official Full Name | interleukin 2 receptor subunit alpha |
| Also known as | interleukin 2 receptor subunit alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000134460 MIM:147730; AllianceGenome:HGNC:6008 |
| Map Location | 10p15.1 |
| Variation Type | SNP |
| refSNP ID | rs12722489 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood leucocytes |
| Sample Detail | N/A |
| Detected Method | high multiplexed iPlexes |
| Disease | MS |
| Disease subtype | N/A |
| Population | German and French |
| Sample Size | 206 MS patients / 540 MS trios / 605 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 18354419 |
| Year | 2008 |
| Title | IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The SNP rs12722489, also located within the IL2RA gene, shows significant association in the German sample and a positive trend in the French trios. |
| Mechanism/Pathway | Variations in the interleukin-2 receptor-a gene (IL2RA) were demonstrated to confer a risk for MS in candidate gene approaches and a whole genome screen. |
