Basic information of LTA :
| Official Symbol of Gene | LTA |
| Species | Homo sapiens |
| Entrez Gene ID | 4049 |
| Official Full Name | lymphotoxin alpha |
| Also known as | LT; TNFB; TNFSF1; TNLG1E |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000226979 MIM:153440; AllianceGenome:HGNC:6709 |
| Map Location | 6p21.33 |
| Variation Type | allele |
| refSNP ID | TNF-β +252 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood leukocytes |
| Sample Detail | N/A |
| Detected Method | PCR-RFLP |
| Disease | MS |
| Disease subtype | RRMS, PPMS, SPMS |
| Population | Iranian |
| Sample Size | 270 MS patients / 542 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 17295710 |
| Year | 2007 |
| Title | TNF-alpha, TNF-beta and IL-4 gene polymorphisms in Iranian patients with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | Allelic and genotypic frequencies for this polymorphism was similar in patients with MS and population controls or among different types of the disease. The mentioned functional polymorphism is not likely to cause susceptibility to MS in the Iranian population. |
| Mechanism/Pathway | Pro-inflammatory cytokines, such as tumor necrosis factor-b (TNF-b), has a detrimental role in MS induction. |
