Basic information of HLA-DRB1 :

Official Symbol of Gene	HLA-DRB1
Species	Homo sapiens
Entrez Gene ID	3123
Official Full Name	major histocompatibility complex, class II, DR beta 1
Also known as	SS1; DRB1; HLA-DRB; HLA-DR1B
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948
Map Location	6p21.32
Variation Type	allele
refSNP ID	DRB11501

Sample information of multiple sclerosis:

Detected Sample	leukocyte
Sample Detail	N/A
Detected Method	PCR/SSO
Disease	MS
Disease subtype	PPMS
Population	African descent and whites
Sample Size	33 MS patients / 180 controls

Literature information of multiple sclerosis :

Pubmed ID	1961631
Year	2009
Title	Does the DRB1*1501 allele confer more severe and faster progression in primary progressive multiple sclerosis patients? HLA in primary progressive multiple sclerosis

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Positive
Result	An association was found between PPMS and DRB1*1501 allele.Severe morbidity was found in DRB1*1501-positive PPMS patients. Stratification according to ethnic group showed DRB11501 to be significantly associated with PPMS irrespective of ethnicity.
Mechanism/Pathway	The heterogeneity found in multiple sclerosis patients with respect to clinical presentation and temporal progression may be a consequence of the complex interaction between the genetic and environmental factors affecting its prevalence, geographical distribution and severity.The effect of HLA alleles on the outcome of the disease has been investigated in several studies;