Basic information of HLA-DQB1 :
| Official Symbol of Gene | HLA-DQB1 |
| Species | Homo sapiens (human) |
| Entrez Gene ID | 3119 |
| Official Full Name | major histocompatibility complex, class II, DQ beta 1 |
| Also known as | IDDM1; CELIAC1; HLA-DQB |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000179344 MIM:604305; AllianceGenome:HGNC:4944 |
| Map Location | 6p21.32 |
| Variation Type | allele |
| refSNP ID |
DQB1 |
Sample information of multiple sclerosis:
| Detected Sample | leukocyte |
| Sample Detail | N/A |
| Detected Method | PCR/SSO |
| Disease | MS |
| Disease subtype | PPMS |
| Population | African descent and whites |
| Sample Size | 33 MS patients / 180 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 1961631 |
| Year | 2009 |
| Title | Does the DRB1*1501 allele confer more severe and faster progression in primary progressive multiple sclerosis patients? HLA in primary progressive multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result |
With respect to the HLA alleles, an association was found between PPMS and DQB1 |
| Mechanism/Pathway | The heterogeneity found in multiple sclerosis patients with respect to clinical presentation and temporal progression may be a consequence of the complex interaction between the genetic and environmental factors affecting its prevalence, geographical distribution and severity.The effect of HLA alleles on the outcome of the disease has been investigated in several studies; |
