Basic information of GFI1 :

Official Symbol of Gene	GFI1
Species	Homo sapiens
Entrez Gene ID	2672
Official Full Name	growth factor independent 1 transcriptional repressor
Also known as	SCN2; GFI-1; GFI1A; ZNF163
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000162676 MIM:600871; AllianceGenome:HGNC:4237
Map Location	1p22.1
Variation Type	SNP
refSNP ID	rs11804321

Sample information of multiple sclerosis:

Detected Sample	PBMC
Sample Detail	N/A
Detected Method	Chromatin Conformation Capture (3C) assays
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	N/A

Literature information of multiple sclerosis :

Pubmed ID	21602820
Year	2011
Title	Genome-wide CTCF distribution in vertebrates defines equivalent sites that aid the identification of disease-associated genes

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Positive
Result	In PBMCs of the risk (G) allele within SNP rs11804321, the expression of GFI1 was increased, as compared to the levels found in samples carrying the protective (A) allele either in heterozygosity or in homozygozity.
Mechanism/Pathway	MS is a heterogeneous immunopathy likely caused by the joint participation of different peripheral blood cells in the central nervous system.Interestingly, malfunction of GFI1, which encodes a zinc-finger transcription factor, causes abnormal or malignant haematopoiesis, and therefore could play a role in an autoimmune disease such as MS.