Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | allele |
| refSNP ID | DRB1*15 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | Infinium 660K BeadChip or HumanOmniExpress BeadChip |
| Disease | POMS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 334 POMS cases and 565 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 35000467 |
| Year | 2022 |
| Title | Gene-environment interactions increase the risk of pediatric-onset multiple sclerosis associated with ozone pollution |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | Without high ozone exposure, the presence of HLA-DRB1*15 alleles did not significantly increase the odds of POMS.When both HLA-DRB1*15 alleles and high ozone exposure were present, the odds of having POMS increased to 3.89. |
| Mechanism/Pathway | N/A |
