Basic information of PTAFR :

Official Symbol of Gene	PTAFR
Species	Homo sapiens
Entrez Gene ID	5724
Official Full Name	platelet activating factor receptor
Also known as	PAFR
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000169403 MIM:173393; AllianceGenome:HGNC:9582
Map Location	1p35.3
Variation Type	polymorphism
refSNP ID	A224D

Sample information of multiple sclerosis:

Detected Sample	leukocytes
Sample Detail	N/A
Detected Method	PCR-RFLP
Disease	MS
Disease subtype	N/A
Population	Japanese
Sample Size	162 MS patients / 245 healthy controls

Literature information of multiple sclerosis :

Pubmed ID	15748960
Year	2004
Title	Platelet-activating factor receptor gene polymorphism in Japanese patients with multiple sclerosis

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Positive
Result	The frequency of the AD/DD genotypes was significantly higher in MS patients than in healthy controls.Moreover, the frequency of D allele in MS patients was also significantly higher than those in healthy controls.
Mechanism/Pathway	PAF is a very potent chemotactic stimulant for inflammatory cells such as eosinophils and polymorphonuclear neutrophils. PAF not only promotes leukocyte adhesion and transmigration by the induction of intracellular adhesion molecule-1 (ICAM-1) on endothelial cells, but also upregulates major histocompatibility complex (MHC) class I and II expressions in some brain cells thatare critical in antigen presentation.These proinflammatory and vasoactive actions of PAF are mediated through a specific G-protein-coupled receptor, PAFR .