Basic information of TNF :
| Official Symbol of Gene | TNF |
| Species | Homo sapiens |
| Entrez Gene ID | 7124 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000232810 MIM:191160; AllianceGenome:HGNC:11892 |
| Map Location | 6p21.33 |
| Variation Type | polymorphism |
| refSNP ID | TNF1/l ,TNF1 /2 ,TNF2/2 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | allelespecific PCR (ASPCR) |
| Disease | MS |
| Disease subtype | PCP MS,RRMS |
| Population | Swedish |
| Sample Size | 93 patients with MS / 95 healthy individuals |
Literature information of multiple sclerosis :
| Pubmed ID | 8550811 |
| Year | 1995 |
| Title | Tumor necrosis factor alpha-308 alleles in multiple sclerosis and optic neuritis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | No significant difference regarding the TNF alpha-308 polymorphism was observed between MS patients and controls. |
| Mechanism/Pathway | Variations in the region responsible for transcriptional regulation may have implications for the levels of TNF-(r gene expression, and variability of TNF-a synthesis could be an important factor in the pathogenesis of MS . |
