Basic information of SYN3 :
| Official Symbol of Gene | SYN3 |
| Species | Homo sapiens |
| Entrez Gene ID | 8224 |
| Official Full Name | synapsin III |
| Also known as | N/A |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000185666 MIM:602705; AllianceGenome:HGNC:11496 |
| Map Location | 22q12.3 |
| Variation Type | SNP |
| refSNP ID | g–631 (C > G) |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS/RPMS/PPMS |
| Population | Italian |
| Sample Size | 191 MS patients/270 HCs |
Literature information of multiple sclerosis :
| Pubmed ID | 14991350 |
| Year | 2004 |
| Title | Association between Synapsin III gene promoter polymorphisms and multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | A significant association with MS was observed for the g.–631 polymorphism.The C allele of the g.–631 polymorphism occurred less frequently in patients than in controls, and subjects who were carrying at least one C allele had a reduced risk of developing MS.The C allele of the g.–631C >G polymorphism was less frequent in the cases, and that individuals carrying the C allele were at reduced risk for developing MS. |
| Mechanism/Pathway | Synapsins are a family of abundant neuron-specific phosphoproteins, that have been recognised as playing crucial roles in synaptogenesis and neuronal plasticity, including regulation of synapse development, modulation of neurotransmitter release and formation of nerve terminals. |
