Basic information of Val158Met :
| Official Symbol of Gene | Val158Met |
| Species | Homo sapiens |
| Entrez Gene ID | 1312 |
| Official Full Name | catechol-O-methyltransferase |
| Also known as | HEL-S-98n |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000093010 MIM:116790; AllianceGenome:HGNC:2228 |
| Map Location | 22q11.21 |
| Variation Type | polymorphism |
| refSNP ID | rs4680 Val158Met (Val/Val, Val/Met,and Met/Met) |
Sample information of multiple sclerosis:
| Detected Sample | saliva |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 108 MS patients( MS with pain (N = 58),MS without pain (N = 50))/ 108 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 24290452 |
| Year | 2013 |
| Title | Catechol-O-methyltransferase Val158Met polymorphism (rs4680) is associated with pain in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | Distribution of rs4680 Val158Met genotypes was not significantly different between individuals with MS in general and healthy people. |
| Mechanism/Pathway | N/A |
