Basic information of Val158Met :

Official Symbol of Gene	Val158Met
Species	Homo sapiens
Entrez Gene ID	1312
Official Full Name	catechol-O-methyltransferase
Also known as	HEL-S-98n
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000093010 MIM:116790; AllianceGenome:HGNC:2228
Map Location	22q11.21
Variation Type	polymorphism
refSNP ID	rs4680 Val158Met (Val/Val, Val/Met,and Met/Met)

Sample information of multiple sclerosis:

Detected Sample	saliva
Sample Detail	N/A
Detected Method	PCR
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	108 MS patients( MS with pain (N = 58),MS without pain (N = 50))/ 108 healthy controls

Literature information of multiple sclerosis :

Pubmed ID	24290452
Year	2013
Title	Catechol-O-methyltransferase Val158Met polymorphism (rs4680) is associated with pain in multiple sclerosis

Results of multiple sclerosis :

Risk Type	Phenotypic risk
Main Result	Positive
Result	This study suggests that the Val158Met polymorphism is associated with the presence of pain in MS, because the presence of the Met/Met genotype was more prevalent in those patients with pain.
Mechanism/Pathway	The catechol-Omethyltransferase (COMT) gene is one of the several potential genetic determinants of nociceptive modulation.Genetic polymorphism due to a G/A substitution at codon 158 of the COMT gene, leading to a Val to Met substitution, results in gene activity differences.The presence of a Met allele results in low enzymatic activity.