Basic information of IL2 :
| Official Symbol of Gene | IL2 |
| Species | Homo sapiens |
| Entrez Gene ID | 3558 |
| Official Full Name | interleukin 2 |
| Also known as | IL-2; TCGF; lymphokine |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000109471 MIM:147680; AllianceGenome:HGNC:6001 |
| Map Location | 4q27 |
| Variation Type | allele |
| refSNP ID | IL2 -330 GT , TT ,GG |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | PCR-RFLP |
| Disease | MS |
| Disease subtype | RRMS,SPMS |
| Population | Spanish Caucasoid |
| Sample Size | 23 MS patients / 32 HCs |
Literature information of multiple sclerosis :
| Pubmed ID | 14975604 |
| Year | 2003 |
| Title | Effects of the multiple sclerosis associated -330 promoter polymorphism in IL2 allelic expression |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The higher expression of IL2 -330 GT and TT genotypes, associated with susceptibility to MS, and the altered relative expression between alleles in MS patients supports the importance of IL2 in the MS. |
| Mechanism/Pathway | Importance of IL-2/IL-2R system for the T cell homeostasis at the levels of repertoire selection, the generation of suppressive regulatory T cells, T cell homing and clonal contraction via activation induced cell death indicates its relevance in the development of autoimmune disease. |
