Basic information of HLA-DRB1 :

Official Symbol of Gene	HLA-DRB1
Species	Homo sapiens
Entrez Gene ID	3123
Official Full Name	major histocompatibility complex, class II, DR beta 1
Also known as	SS1; DRB1; HLA-DRB; HLA-DR1B
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948
Map Location	6p21.32
Variation Type	allele
refSNP ID	DRBl*I501,DRBS*0I01,DQAl*OlO2,DQB1*0602

Sample information of multiple sclerosis:

Detected Sample	N/A
Sample Detail	N/A
Detected Method	RFLP and PCR-SSP
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	55 MS patients / 30 HCs

Literature information of multiple sclerosis :

Pubmed ID	8560455
Year	1995
Title	The multiple sclerosis- and narcolepsy-associated HLA class II haplotype includes the DRB5*0101 allele

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Positive
Result	All Dw2-positive MS patients and control subjects carried the DRBl* 1501 allele.All Dw2-positive patients as well as the 30 Dw2-positive controls carried the DRBS *0101 allele.The Dw2 haplotype was found to include the DRBS*OlOl allele in all the sixteen Dw2 homozygous MS patients and six Dw2 homozygous healthy controls. We have found that the HLA-Dw2 haplotype in MS patients extends to the DRB5 locus. The haplotype associated with MS can thus be specified as DRBl*I501,DRBS*0I01,DQAl*OlO2,DQB1*0602.
Mechanism/Pathway	N/A