Basic information of NOS1 :
| Official Symbol of Gene | NOS1 |
| Species | Homo sapiens |
| Entrez Gene ID | 4842 |
| Official Full Name | nitric oxide synthase 1 |
| Also known as | NOS; bNOS; nNOS; IHPS1; N-NOS; NC-NOS |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000089250 MIM:163731; AllianceGenome:HGNC:7872 |
| Map Location | 12q24.22 |
| Variation Type | allele |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS,PPMS,SPMS |
| Population | Caucasian Australian |
| Sample Size | 104 MS / 104HCs |
Literature information of multiple sclerosis :
| Pubmed ID | 14759629 |
| Year | 2007 |
| Title | Comparative expression of human endogenous retrovirus-W genes in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | In this Australian population,13 alleles of this polymorphism were identified. This analysis indicates that the nNOS variant does not confer an altered effect on MS. Rank analysis also indicated that allelic distributions were not significantly different between test groups. Stratified analyses testing for a gender-specific relationship between MS and nNOS and comparisons of a specific clinical course group were also negative for association. |
| Mechanism/Pathway | Nitric oxide (NO) production arising from nNOS has been involved in the pathophysiology of several disorders of the brain.NO has been shown to be toxic to oligodendrocytes and to induce axonal degeneration.Nitric oxide is also known to be a modulator of neuronal function affecting the release of neurotransmitters. |
