Basic information of NINJ2 :
| Official Symbol of Gene | NINJ2 |
| Species | Homo sapiens |
| Entrez Gene ID | 4815 |
| Official Full Name | ninjurin 2 |
| Also known as | N/A |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000171840 MIM:607297; AllianceGenome:HGNC:7825 |
| Map Location | 12p13.33 |
| Variation Type | SNP |
| refSNP ID | rs11833579 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | ARMS-PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Iranian |
| Sample Size | 410 MS patients/410 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 31292852 |
| Year | 2019 |
| Title | A single nucleotide polymorphism within Ninjurin 2 is associated with risk of multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | There were no significant difference in the alleles and genotypes frequencies of rs11833579 between cases and controls.Based on the D’ and r statistics, the mentioned SNPS were not in strong linkage disequilibrium. |
| Mechanism/Pathway | Ninjurin 2 (NINJ2) participates in the process of nerve regeneration after nerve damage.As a protein which regulates the attachment of monocytes to endothelial cells and thus controls the relocation of immune cells to the CNS. Notably, based on the results of co-expression investigations, NINJ2 participates in immune system-associated pathways. Therefore, NINJ2 has prominent roles in nerve regeneration, immune response regulation and development of MS. |
