Basic information of NINJ2 :

Official Symbol of Gene	NINJ2
Species	Homo sapiens
Entrez Gene ID	4815
Official Full Name	ninjurin 2
Also known as	N/A
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000171840 MIM:607297; AllianceGenome:HGNC:7825
Map Location	12p13.33
Variation Type	SNP
refSNP ID	rs3809263

Sample information of multiple sclerosis:

Detected Sample	peripheral blood
Sample Detail	N/A
Detected Method	ARMS-PCR
Disease	MS
Disease subtype	RRMS
Population	Iranian
Sample Size	410 MS patients/410 healthy controls

Literature information of multiple sclerosis :

Pubmed ID	31292852
Year	2019
Title	A single nucleotide polymorphism within Ninjurin 2 is associated with risk of multiple sclerosis

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Positive
Result	The frequency of T allele of the rs3809263 was significantly higher in MS patients compared with healthy subjects.TT genotype of this SNP was associated with MS risk compared with CC genotype. Moreover, the rs3809263 was associated with MS risk in recessive model.
Mechanism/Pathway	Ninjurin 2 (NINJ2) participates in the process of nerve regeneration after nerve damage.As a protein which regulates the attachment of monocytes to endothelial cells and thus controls the relocation of immune cells to the CNS. Notably, based on the results of co-expression investigations, NINJ2 participates in immune system-associated pathways. Therefore, NINJ2 has prominent roles in nerve regeneration, immune response regulation and development of MS.