Basic information of Tcrb :

Official Symbol of Gene	Tcrb
Species	Rattus norvegicus
Entrez Gene ID	24820
Official Full Name	T-cell receptor beta chain
Also known as	TCB; TCBC1; RATTCB; RATTCBC1
Gene Type	protein coding
dbXrefs	N/A
Map Location	4q22
Variation Type	allele
refSNP ID	TcR Vβ，TcR Cβ

Sample information of multiple sclerosis:

Detected Sample	liver samples
Sample Detail	N/A
Detected Method	Southern blots,RFLP
Disease	EAE
Disease subtype	N/A
Population	LEW,LER rat
Sample Size	N/A

Literature information of multiple sclerosis :

Pubmed ID	1716210
Year	1991
Title	Genetic differences in the T cell receptor alleles of LEW rats and their encephalomyelitis-resistant derivative, LER, and their impact on the inheritance of EAE resistance

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Positive
Result	TcR beta allele from the susceptible strain was present in three out of four susceptible rats, suggesting that it is an important, but not the only, genetic factor in EAE.12 of 13 rats with homozygous LER-derived TCR beta alleles were resistant to EAE.
Mechanism/Pathway	Coding region differences contribute to a change in function of these TcR molecules, such structural changes could lead to a loss of pathogenicity of the Tcells bearing them.