Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | genotype |
| refSNP ID | DR1 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | PCR-SSP |
| Disease | MS |
| Disease subtype | N/A |
| Population | Gothenburg, Swedish |
| Sample Size | MS patients (n=78 ,Siblings with MSIT (n=14), Non-MSIT siblings (n=64)), Controls (n=50) |
Literature information of multiple sclerosis :
| Pubmed ID | 17463066 |
| Year | 2007 |
| Title | Multiple sclerosis immunopathic trait and HLA-DR(2)15 as independent risk factors in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Phenotype risk |
| Main Result | Negative |
| Result | These results suggest that the MS susceptibility gene, HLA-DR(2)15 type, does not induce MSIT, and conceivably these are two separate risk factors in the development of MS. |
| Mechanism/Pathway | Hence, the HLA locus may be involved in the initialpathogenic events, while other candidate QTL, such as those postulated for MSIT, influence the development and progression of the disease. |
