Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | allele |
| refSNP ID | residue 86 polymorphism |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | PCR-SSP |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Australian |
| Sample Size | 100 MS/105 HCs |
Literature information of multiple sclerosis :
| Pubmed ID | 10439317 |
| Year | 1999 |
| Title | The DRB1 Val86/Val86 genotype associates with multiple sclerosis in Australian patients |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | There was a highly significant increase in the Val/Val genotype in the MS patients and a significant decrease in the Gly/Gly genotype.The Val/Gly genotype was decreased in the MS patients, though not significantly.There was also a highly significant decrease in the Gly phenotype in the MS patients and a significant increase in the Val phenotype. |
| Mechanism/Pathway | N/A |
