Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | SNP |
| refSNP ID | rs3135388 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | qRTâ€PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Southern Italy |
| Sample Size | 20 patients/7 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 31313885 |
| Year | 2019 |
| Title | The HLA-DRB1 risk alleles for multiple sclerosis are differentially expressed in blood cells of patients from Southern Italy |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | The results show that only two patients with the HLAâ€HLAâ€DRB1*13 allele and three with the HLA-DRB1*15 allele carried the specific variant in heterozygosis (A/G).All individuals, either patients or controls carrying the HLAâ€DRB1*11 allele, had the nonrisk GG genotype. |
| Mechanism/Pathway | In multiple sclerosis, the diseaseâ€associated HLAâ€DR heterodimers play a pivotal role in presenting immunogenic peptides from myelin proteins to pathogenic CD4+ T cells. |
