Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | allele |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | N/A |
| Sample Detail | N/A |
| Detected Method | N/A |
| Disease | MS |
| Disease subtype | N/A |
| Population | Sardinian |
| Sample Size | 1097 MS /329 HCs |
Literature information of multiple sclerosis :
| Pubmed ID | 15452304 |
| Year | 2004 |
| Title | Bias in parental transmission of the HLA-DR3 allele in Sardinian multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Phenotypic risk |
| Main Result | Positive |
| Result | Female/male distribution varied between the DR3/DR3 and DR4/DRY and between the DR3/DRX and DR4/DRY groups.An excess of paternally transmitted DR3 in affected but not in healthy offspring was found. No evidence of a PO effect in transmission of DR4 in affected or healthy sibs was found.A PO effect on DR3 transmission from fathers was evident in women but not in men. Moreover, an effect of two copies of the maternal non-transmitted DR3 genotype was found in DR3 females but not in males. |
| Mechanism/Pathway | N/A |
