Basic information of MBP :
| Official Symbol of Gene | MBP |
| Species | Homo sapiens |
| Entrez Gene ID | 4155 |
| Official Full Name | myelin basic protein |
| Also known as | N/A |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000197971 MIM:159430; AllianceGenome:HGNC:6925 |
| Map Location | 18q23 |
| Variation Type | polymorphism |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS,PPMS |
| Population | Italian |
| Sample Size | 171 MS/236 HCs |
Literature information of multiple sclerosis :
| Pubmed ID | 10871781 |
| Year | 2000 |
| Title | A polymorphism in the repetitive (TGGA)n sequence 5' to the human myelin basic protein gene in Italian multiple sclerosis patients |
Results of multiple sclerosis :
| Risk Type | Disease risk ,Phenotypic risk |
| Main Result | Positive |
| Result | The results of ourstudy indicate a signicantly different distributionof the hMBP polymorphism pattern in relapsing remitting MS patients compared to healthy controls.More specically, the short 354 bp hMBP frag-ment was more frequent in relapsing remitting MS patients than in primary chronic progressive MS and controls,whereas the long 424 bp hMBP fragment was more frequent than the short one inthe whole population studied and particularly inthe healthy controls. |
| Mechanism/Pathway | Human myelin basic protein (hMBP) could act as anautoantigen and thus intervene in the pathogenicmechanism of multiple sclerosis (MS), moreover thehMBP gene has been suggested as one of the genesinvolved in MS susceptibility. |
