Basic information of CCL2 :
| Official Symbol of Gene | CCL2 |
| Species | Homo sapiens |
| Entrez Gene ID | 6347 |
| Official Full Name | C-C motif chemokine ligand 2 |
| Also known as | HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000108691 MIM:158105; AllianceGenome:HGNC:10618 |
| Map Location | 17q12 |
| Variation Type | SNP |
| refSNP ID | -2138A>T |
Sample information of multiple sclerosis:
| Detected Sample | whole blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS,PPMS,SPMS |
| Population | European |
| Sample Size | 208 Australian MS trio families |
Literature information of multiple sclerosis :
| Pubmed ID | 16872505 |
| Year | 2006 |
| Title | An investigation of polymorphisms in the 17q11.2-12 CC chemokine gene cluster for association with multiple sclerosis in Australians |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | We also identified marginally significant (uncorrected) transmission distortion for haplotypes encompassing the CCL2 genes. |
| Mechanism/Pathway | CC chemokines chemoattract a wide range of cells, including lymphocytes, dendritic cells, monocytes and some granulocytes, whilst CXC chemokines are chemoattractant for neutrophils and lymphocytes. There is increasing evidence for chemokines possessing abilities beyond that of migration, including T-helper cell subset differentiation, T cell costimulation, and macrophage and natural killer cell maturation .Substantial evidence supports the involvement of CC chemokines in the pathogenesis of MS. |
