Basic information of TNF :
| Official Symbol of Gene | TNF |
| Species | Homo sapiens |
| Entrez Gene ID | 7124 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000232810 MIM:191160; AllianceGenome:HGNC:11892 |
| Map Location | 6p21.33 |
| Variation Type | allele |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Caucasian |
| Sample Size | 110 patients / 110 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 9270614 |
| Year | 1997 |
| Title | A population-based case-control study of the tumor necrosis factor alpha-308 polymorphism in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | There were no statistically significant differences between the TNF2 allelic frequencies in the groups of patients with MS. |
| Mechanism/Pathway | Tumor necrosis factor alpha (TNFa) is a proinflammatory cytokine produced by the TH1 subset of T-helper lymphocytes. It has been implicated in the pathogenesis and course of several immunemediated diseases, including MS. |
