Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | allele |
| refSNP ID | DRB1*1501-positive and -negative |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR followed by restriction fragment length polymorphisms techniques |
| Disease | MS |
| Disease subtype | CIS-MS,RRMS,PPMS,SPMS |
| Population | European |
| Sample Size | 583 MS patients |
Literature information of multiple sclerosis :
| Pubmed ID | 21179117 |
| Year | 2010 |
| Title | HLA (A-B-C and -DRB1) alleles and brain MRI changes in multiple sclerosis: a longitudinal study |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | The comparison between HLA DRB1*1501-positive and - negative MS patients did not show significant differences for age, gender, age at disease onset and clinical MS subtype. No significant effect of HLA DRB1*1501 status was found on clinical (Extended Disability Status Scale, MS Severity Score (MSSS)) and cognitive (SDMT) disabilities. |
| Mechanism/Pathway | N/A |
