Basic information of HLA-B :
| Official Symbol of Gene | HLA-B |
| Species | Homo sapiens |
| Entrez Gene ID | 3106 |
| Official Full Name | major histocompatibility complex, class I, B |
| Also known as | AS; HLAB; B-4901 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000234745 MIM:142830; AllianceGenome:HGNC:4932 |
| Map Location | 6p21.33 |
| Variation Type | allele |
| refSNP ID | HLA B*44 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR followed by restriction fragment length polymorphisms techniques |
| Disease | MS |
| Disease subtype | CIS-MS,RRMS,PPMS,SPMS |
| Population | European |
| Sample Size | 583 MS patients |
Literature information of multiple sclerosis :
| Pubmed ID | 21179117 |
| Year | 2010 |
| Title | HLA (A-B-C and -DRB1) alleles and brain MRI changes in multiple sclerosis: a longitudinal study |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | HLA B*44 also have consistent effects on MRI parameters in the entire MS population. Subjects carrying HLA B*44 were also significantly associated with better performance on Symbol Digit Modalities Test (SDMT). |
| Mechanism/Pathway | HLA B*44 has been shown to modulate the immune response. |
