Basic information of IFNL3 :
| Official Symbol of Gene | IFNL3 |
| Species | Homo sapiens |
| Entrez Gene ID | 282617 |
| Official Full Name | interferon lambda 3 |
| Also known as | IL28B; IL28C; IL-28B; IL-28C; IFN-lambda-3; IFN-lambda-4 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000197110 MIM:607402; AllianceGenome:HGNC:18365 |
| Map Location | 19q13.2 |
| Variation Type | SNP |
| refSNP ID | rs12979860 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | N/A |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 588 MS patients classified into responders (n=281) and non-responders (n=307) to IFNβ |
Literature information of multiple sclerosis :
| Pubmed ID | 21889215 |
| Year | 2011 |
| Title | IL28B polymorphisms are not associated with the response to interferon-β in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Treatment risk |
| Main Result | Negative |
| Result | Combined analysis of the study cohorts showed no significant associations between SNP rs12979860 and the response to treatment. |
| Mechanism/Pathway | The IL28B gene codes for IFN-lambda 3 (IFN-λ-3), a cytokine induced by viral infections that is related with the type I IFNs and the IL-10 family. |
