Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | allele-haplotype |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | buffy coat cells |
| Sample Detail | N/A |
| Detected Method | RFLP,PCR |
| Disease | MS |
| Disease subtype | RRMS,PPMS,SPMS |
| Population | Caucasian |
| Sample Size | 119 patients / 100 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 9748020 |
| Year | 1998 |
| Title | Major histocompatibility complex class II alleles and the course and outcome of MS: a population-based study |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | We found a negative association between MS susceptibility and DR1-DQ5 haplotype. |
| Mechanism/Pathway | The class II MHC proteins, the major restriction elements for cell-mediated immunity, have a pivotal role in development of the T-cell repertoire during ontogeny and subsequently in immune recognition. Hence, MHC genes are plausible candidate genes that could influence the outcome of an immune-mediated disease such as MS. |
