Basic information of HLA-DQB1 :
| Official Symbol of Gene | HLA-DQB1 |
| Species | Homo sapiens (human) |
| Entrez Gene ID | 3119 |
| Official Full Name | major histocompatibility complex, class II, DQ beta 1 |
| Also known as | IDDM1; CELIAC1; HLA-DQB |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000179344 MIM:604305; AllianceGenome:HGNC:4944 |
| Map Location | 6p21.32 |
| Variation Type | allele-haplotype |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | buffy coat cells |
| Sample Detail | N/A |
| Detected Method | RFLP,PCR |
| Disease | MS |
| Disease subtype | RRMS,PPMS,SPMS |
| Population | Caucasian |
| Sample Size | 119 patients / 100 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 9748020 |
| Year | 1998 |
| Title | Major histocompatibility complex class II alleles and the course and outcome of MS: a population-based study |
Results of multiple sclerosis :
| Risk Type | Phenotypic risk |
| Main Result | Positive |
| Result | We found a trend to a positive association of primary progressive MS with DR4-DQ8 and DR1-DQ5 and an association of "bout onset" MS with DR17-DQ2. |
| Mechanism/Pathway | The class II MHC proteins, the major restriction elements for cell-mediated immunity, have a pivotal role in development of the T-cell repertoire during ontogeny and subsequently in immune recognition. Hence, MHC genes are plausible candidate genes that could influence the outcome of an immune-mediated disease such as MS. |
