Basic information of Ncf1 :
| Official Symbol of Gene | Ncf1 |
| Species | Mus musculus |
| Entrez Gene ID | 17969 |
| Official Full Name | neutrophil cytosolic factor 1 |
| Also known as |
NOXO2; Ncf-1; NCF-47K; p47phox; p47-phox; p47 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000015950 AllianceGenome:MGI:97283 |
| Map Location | 5 G2; 5 74.47 cM |
| Variation Type | allele |
| refSNP ID | amino acid replacements at position 106 and 153 |
Sample information of multiple sclerosis:
| Detected Sample | toe biopsies |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6J-m+/+ Leprdb,B10.Q mice |
| Sample Size | MOG peptide 79–96 in CFA B10.Q.Ncf1*/* (n = 13) / B10.Q.Ncf1+/* (n = 9) / B10.Q.Ncf1+/+ (n = 12); native MOG recombinant protein in CFA B10.Q.Ncf1*/* (n = 13) / B10.Q.Ncf1+/* (n = 7) / B10.Q.Ncf1+/+ (n = 4). |
Literature information of multiple sclerosis :
| Pubmed ID | 15310853 |
| Year | 2004 |
| Title | Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene |
Results of multiple sclerosis :
| Risk Type | Phenotypic risk |
| Main Result | Positive |
| Result | MOG79–96 peptide-induced EAE was milder in the Ncf1-mutated mice than in the wild-type control.However, induction of EAE with MOG protein induced a more severe chronic EAE in the Ncf1-mutated mice. |
| Mechanism/Pathway | Ncf1 has a more general role in regulating autoimmune inflammation and also suggests that the effect of Ncf1 is related to the function of antigen-presenting cells (APC) in processing and presenting autoantigens to T cells. |
