Basic information of IL2RA :
| Official Symbol of Gene | IL2RA |
| Species | Homo sapiens |
| Entrez Gene ID | 3559 |
| Official Full Name | interleukin 2 receptor subunit alpha |
| Also known as | interleukin 2 receptor subunit alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000134460 MIM:147730; AllianceGenome:HGNC:6008 |
| Map Location | 10p15.1 |
| Variation Type | methylation |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood mononuclear cells |
| Sample Detail | N/A |
| Detected Method | Illumina HumanMethylation 450k DNA Methylation Chip |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 14 MS / 14HCs |
Literature information of multiple sclerosis :
| Pubmed ID | 28077880 |
| Year | 2017 |
| Title | Interleukin-2 receptor-α proximal promoter hypomethylation is associated with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | DNA methylation of IL2RA is decreased in T cells of MS patients compared with healthy controls.The degree of hypomethylation was differential between cases and controls at cg26316423, being more overt in those with MS. |
| Mechanism/Pathway | Genetic studies have demonstrated association between single-nucleotide polymorphisms within the IL2RA (interleukin-2 receptor α-subunit) gene and risk of developing multiple sclerosis (MS). |
