Basic information of IFNAR1 :
| Official Symbol of Gene | IFNAR1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3454 |
| Official Full Name | interferon alpha and beta receptor subunit 1 |
| Also known as | AVP; IFRC; IFNAR; IFNBR; IMD106; IFN-alpha-REC |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000142166 MIM:107450; AllianceGenome:HGNC:5432 |
| Map Location | 21q22.11 |
| Variation Type | SNP |
| refSNP ID | rs2850015 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Iranian |
| Sample Size | 57 IFN-β responders / 43 non-responders |
Literature information of multiple sclerosis :
| Pubmed ID | 34328599 |
| Year | 2021 |
| Title | Association study of promoter polymorphisms of interferon alpha and beta receptor subunit 1 (IFNAR1) gene and therapeutic response to interferon-beta in patients with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Treatment risk |
| Main Result | Positive |
| Result | rs2850015 SNP indicated a statistically signifcant diference between the responders and non-responders.There was a signifcant diference between the responders and non-responders concerning the TC genotype.The results implied that compared to the CC genotype, the probability of response to treatment was higher in the TC genotype. |
| Mechanism/Pathway | IFN-β binds to type I interferon receptors and persuades a complex transcriptional response, allowing multiple immunomodulatory proteins expression. Thus, up-or down-regulation of the IFNAR1 and IFNAR2 receptors could afect the IFN-β therapy. |
